Hochfrequenzforschung

Oberacker E, Kuehne A, Oezerdem C, Nadobny J, Weihrauch M, Beck B, Zschaeck S,

Diesch C, Eigentler TW, Waiczies H, Ghadjar P, Wust P, Winter L, Niendorf T.

Radiofrequency applicator concepts for thermal magnetic resonanceof brain tumors at 297MHz (7.0 Tesla).

Int J Hyperthermia 2020, online publication prior to print

 

Kok HP, Beck M, Löke DR, Helderman RFCPA, van Tienhoven G, Ghadjar P, Wust P,

Crezee H. Locoregional peritoneal hyperthermia to enhance the effectiveness of

chemotherapy in patients with peritoneal carcinomatosis: a simulation study

comparing different locoregional heating systems. Int J Hyperthermia.

2020;37(1):76-88. doi: 10.1080/02656736.2019.1710270. PubMed PMID: 31969039.

 

Wust P, Ghadjar P, Nadobny J, Beck M, Kaul D, Winter L, Zschaeck S. Physical

analysis of temperature-dependent effects of amplitude-modulated electromagnetic

hyperthermia. Int J Hyperthermia. 2019;36(1):1246-1254. doi:

10.1080/02656736.2019.1692376. PubMed PMID: 31818170.

 

Dobšíček Trefná H, Schmidt M, van Rhoon GC, Kok HP, Gordeyev SS, Lamprecht U,

Marder D, Nadobny J, Ghadjar P, Abdel-Rahman S, Kukiełka AM, Strnad V, Hurwitz

MD, Vujaskovic Z, Diederich CJ, Stauffer PR, Crezee J. Quality assurance

guidelines for interstitial hyperthermia. Int J Hyperthermia. 2019;36(1):277-294.

doi: 10.1080/02656736.2018.1564155. Epub 2019 Jan 24. PubMed PMID: 30676101.

 

Zschaeck S, Wust P, Melcher I, Nadobny J, Rau D, Striefler J, Pahl S, Flörcken

A, Kunitz A, Ghadjar P. Neoadjuvant chemotherapy plus radiation versus

chemotherapy plus regional hyperthermia in high-grade soft tissue sarcomas: a

retrospective comparison. Int J Hyperthermia. 2018;35(1):1-9. doi:

10.1080/02656736.2018.1498137. Epub 2018 Oct 9. PubMed PMID: 30300018.

 

Issels RD, Lindner LH, Verweij J, Wessalowski R, Reichardt P, Wust P, Ghadjar

P, Hohenberger P, Angele M, Salat C, Vujaskovic Z, Daugaard S, Mella O, Mansmann

U, Dürr HR, Knösel T, Abdel-Rahman S, Schmidt M, Hiddemann W, Jauch KW, Belka C,

Gronchi A; European Organization for the Research and Treatment of Cancer-Soft

Tissue and Bone Sarcoma Group and the European Society for Hyperthermic Oncology.

Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term

Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC

62961-ESHO 95 Randomized Clinical Trial. JAMA Oncol. 2018 Apr 1;4(4):483-492.

doi: 10.1001/jamaoncol.2017.4996. Erratum in: JAMA Oncol. 2018 Apr 1;4(4):590.

PubMed PMID: 29450452; PubMed Central PMCID: PMC5885262.

 

Hindel S, Papanastasiou G, Wust P, Maaß M, Söhner A, Lüdemann L. Evaluation

of pharmacokinetic models for perfusion imaging with dynamic contrast-enhanced

magnetic resonance imaging in porcine skeletal muscle using low-molecular-weight

contrast agents. Magn Reson Med. 2018 Jun;79(6):3154-3162. doi:

10.1002/mrm.26983. Epub 2017 Nov 2. PubMed PMID: 29096037.

 

Trefná HD, Crezee H, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J,

Nadobny J, Gellermann J, van Holthe N, Ghadjar P, Lomax N, Abdel-Rahman S, Bert

C, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC. Quality

assurance guidelines for superficial hyperthermia clinical trials: I. Clinical

requirements. Int J Hyperthermia. 2017 Jun;33(4):471-482. doi:

10.1080/02656736.2016.1277791. Epub 2017 Jan 31. PubMed PMID: 28049386.

 

Seifert G, Budach V, Keilholz U, Wust P, Eggert A, Ghadjar P. Regional

hyperthermia combined with chemotherapy in paediatric, adolescent and young adult

patients: current and future perspectives. Radiat Oncol. 2016 Apr 30;11:65. doi:

10.1186/s13014-016-0639-1. Review. PubMed PMID: 27138749; PubMed Central PMCID:

PMC4852447.

 

Winter L, Oberacker E, Paul K, Ji Y, Oezerdem C, Ghadjar P, Thieme A, Budach

V, Wust P, Niendorf T. Magnetic resonance thermometry: Methodology, pitfalls and

practical solutions. Int J Hyperthermia. 2016;32(1):63-75. doi:

10.3109/02656736.2015.1108462. Epub 2015 Dec 27. Review. PubMed PMID: 26708630.

 

Crezee J, van Leeuwen CM, Oei AL, van Heerden LE, Bel A, Stalpers LJ, Ghadjar

P, Franken NA, Kok HP. Biological modelling of the radiation dose escalation

effect of regional hyperthermia in cervical cancer. Radiat Oncol. 2016 Feb

2;11:14. doi: 10.1186/s13014-016-0592-z. PubMed PMID: 26831185; PubMed Central

PMCID: PMC4735973.

 

Frick VO, Rubie C, Keilholz U, Ghadjar P. Chemokine/chemokine receptor pair

CCL20/CCR6 in human colorectal malignancy: An overview. World J Gastroenterol.

2016 Jan 14;22(2):833-41. doi: 10.3748/wjg.v22.i2.833. Review. PubMed PMID:

26811629; PubMed Central PMCID: PMC4716081.

 

Winter L, Oezerdem C, Hoffmann W, van de Lindt T, Periquito J, Ji Y, Ghadjar

P, Budach V, Wust P, Niendorf T. Thermal magnetic resonance: physics

considerations and electromagnetic field simulations up to 23.5 Tesla (1GHz).

Radiat Oncol. 2015 Sep 22;10:201. doi: 10.1186/s13014-015-0510-9. PubMed PMID:

26391138; PubMed Central PMCID: PMC4578265.

 

Beck M, Ghadjar P, Weihrauch M, Burock S, Budach V, Nadobny J, Sehouli J,

Wust P. Regional hyperthermia of the abdomen, a pilot study towards the treatment

of peritoneal carcinomatosis. Radiat Oncol. 2015 Jul 30;10:157. doi:

10.1186/s13014-015-0451-3. PubMed PMID: 26223271; PubMed Central PMCID:

PMC4520203.

 

Cihoric N, Tsikkinis A, van Rhoon G, Crezee H, Aebersold DM, Bodis S, Beck M,

Nadobny J, Budach V, Wust P, Ghadjar P. Hyperthermia-related clinical trials on

cancer treatment within the ClinicalTrials.gov registry. Int J Hyperthermia.

2015;31(6):609-14. doi: 10.3109/02656736.2015.1040471. Epub 2015 May 15. PubMed

PMID: 25975276.

 

Rubie C, Kruse B, Frick VO, Kölsch K, Ghadjar P, Wagner M, Grässer F,

Wagenpfeil S, Glanemann M. Chemokine receptor CCR6 expression is regulated by

miR-518a-5p in colorectal cancer cells. J Transl Med. 2014 Feb 21;12:48. doi:

10.1186/1479-5876-12-48. PubMed PMID: 24559209; PubMed Central PMCID: PMC3996063.

 

Winter L, Özerdem C, Hoffmann W, Santoro D, Müller A, Waiczies H, Seemann R,

Graessl A, Wust P, Niendorf T. Design and evaluation of a hybrid radiofrequency

applicator for magnetic resonance imaging and RF induced hyperthermia:

electromagnetic field simulations up to 14.0 Tesla and proof-of-concept at 7.0

Tesla. PLoS One. 2013 Apr 22;8(4):e61661. doi: 10.1371/journal.pone.0061661.

Print 2013. PubMed PMID: 23613896; PubMed Central PMCID: PMC3632575.

 

Frick VO, Rubie C, Kölsch K, Wagner M, Ghadjar P, Graeber S, Glanemann M.

CCR6/CCL20 chemokine expression profile in distinct colorectal malignancies.

Scand J Immunol. 2013 Sep;78(3):298-305. doi: 10.1111/sji.12087. PubMed PMID:

23790181.

 

Vicinus B, Rubie C, Faust SK, Frick VO, Ghadjar P, Wagner M, Graeber S,

Schilling MK. miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and

down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells.

Cancer Lett. 2012 Mar;316(1):105-12. doi: 10.1016/j.canlet.2011.10.031. Epub 2011

Oct 29. PubMed PMID: 22099878.

 

Rubie C, Frick VO, Ghadjar P, Wagner M, Justinger C, Faust SK, Vicinus B,

Gräber S, Kollmar O, Schilling MK. CXC receptor-4 mRNA silencing abrogates

CXCL12-induced migration of colorectal cancer cells. J Transl Med. 2011 Feb

24;9:22. doi: 10.1186/1479-5876-9-22. PubMed PMID: 21349176; PubMed Central

PMCID: PMC3049756.

 

Oliveira Frick V, Rubie C, Ghadjar P, Faust SK, Wagner M, Gräber S, Schilling

MK. Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal

malignancies. Tumour Biol. 2011 Feb;32(1):189-96. doi: 10.1007/s13277-010-0112-y.

Epub 2010 Sep 24. PubMed PMID: 20865359.

 

Ranneberg M, Weiser M, Weihrauch M, Budach V, Gellermann J, Wust P.

Regularized antenna profile adaptation in online hyperthermia treatment. Med

Phys. 2010 Oct;37(10):5382-94. PubMed PMID: 21089774.

 

Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H,

Budach V, Jordan A. Efficacy and safety of intratumoral thermotherapy using

magnetic iron-oxide nanoparticles combined with external beam radiotherapy on

patients with recurrent glioblastoma multiforme. J Neurooncol. 2011

Jun;103(2):317-24. doi: 10.1007/s11060-010-0389-0. Epub 2010 Sep 16. PubMed PMID:

20845061; PubMed Central PMCID: PMC3097345.

 

Rubie C, Frick VO, Ghadjar P, Wagner M, Justinger C, Graeber S, Sperling J,

Kollmar O, Schilling MK. Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6

expression in colorectal liver metastases. World J Gastroenterol. 2011 Jul

14;17(26):3109-16. doi: 10.3748/wjg.v17.i26.3109. PubMed PMID: 21912453; PubMed

Central PMCID: PMC3158410.

 

Johannsen M, Thiesen B, Wust P, Jordan A. Magnetic nanoparticle hyperthermia

for prostate cancer. Int J Hyperthermia. 2010;26(8):790-5. doi:

10.3109/02656731003745740. Epub 2010 Jul 23. Review. PubMed PMID: 20653418.

 

Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, Abdel-Rahman

S, Daugaard S, Salat C, Wendtner CM, Vujaskovic Z, Wessalowski R, Jauch KW, Dürr

HR, Ploner F, Baur-Melnyk A, Mansmann U, Hiddemann W, Blay JY, Hohenberger P;

European Organisation for Research and Treatment of Cancer Soft Tissue and Bone

Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO).

Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised

high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet

Oncol. 2010 Jun;11(6):561-70. doi: 10.1016/S1470-2045(10)70071-1. Epub 2010 Apr

29. PubMed PMID: 20434400; PubMed Central PMCID: PMC3517819.

 

Cho CH, Sreenivasa G, Plotkin M, Pietsch H, Wust P, Lüdemann L. Tumour

perfusion assessment during regional hyperthermia treatment: comparison of

temperature probe measurement with H(2)(15)O-PET perfusion. Int J Hyperthermia.

2010;26(4):404-11. doi: 10.3109/02656731003605662. PubMed PMID: 20367556.

 

Deja M, Ahlers O, Macguill M, Wust P, Hildebrandt B, Riess H, Kerner T.

Changes in hepatic blood flow during whole body hyperthermia. Int J Hyperthermia.

2010;26(2):95-100. doi: 10.3109/02656730903250574. PubMed PMID: 20146563.

 

Wust P, Weihrauch M. Hyperthermia classic commentary: 'Simulation studies

promote technological development of radiofrequency phased array hyperthermia' by

Peter Wust et al., International Journal of Hyperthermia 1996;12:477-494. Int J

Hyperthermia. 2009 Nov;25(7):529-32. doi: 10.3109/02656730903193030. PubMed PMID:

19848615.

 

Jost G, Mensing T, Golfier S, Lawaczeck R, Pietsch H, Hütter J, Cibik L,

Gerlach M, Krumrey M, Fratzscher D, Arkadiev V, Wedell R, Haschke M, Langhoff N,

Wust P, Lüdemann L. Photoelectric-enhanced radiation therapy with

quasi-monochromatic computed tomography. Med Phys. 2009 Jun;36(6):2107-17. PubMed

PMID: 19610300.

 

Lüdemann L, Wust P, Gellermann J. Perfusion measurement using DCE-MRI:

implications for hyperthermia. Int J Hyperthermia. 2008 Feb;24(1):91-6. doi:

10.1080/02656730701836954. Review. PubMed PMID: 18214772.

 

Weihrauch M, Wust P, Weiser M, Nadobny J, Eisenhardt S, Budach V, Gellermann

J. Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a

hybrid MR-HT system. Med Phys. 2007 Dec;34(12):4717-25. PubMed PMID: 18196799.

 

Johannsen M, Jordan A, Wust P, Loening SA. Re: Lyndon Gommersall, Iqbal S.

Shergill, Hashim U. Ahmed et al. Nanotechnology and its relevance to the

urologist. Eur Urol 2007;52:368-75. Eur Urol. 2008 Apr;53(4):860. Epub 2007 Oct

17. PubMed PMID: 17954008.

 

Ghadjar P, Loddenkemper C, Coupland SE, Stroux A, Noutsias M, Thiel E,

Christoph F, Miller K, Scheibenbogen C, Keilholz U. Chemokine receptor CCR6

expression level and aggressiveness of prostate cancer. J Cancer Res Clin Oncol.

2008 Nov;134(11):1181-9. doi: 10.1007/s00432-008-0403-5. Epub 2008 May 9. PubMed

PMID: 18465142.

 

Na IK, Scheibenbogen C, Adam C, Stroux A, Ghadjar P, Thiel E, Keilholz U,

Coupland SE. Nuclear expression of CXCR4 in tumor cells of non-small cell lung

cancer is correlated with lymph node metastasis. Hum Pathol. 2008

Dec;39(12):1751-5. doi: 10.1016/j.humpath.2008.04.017. Epub 2008 Aug 12. PubMed

PMID: 18701133.

 

Na IK, Busse A, Scheibenbogen C, Ghadjar P, Coupland SE, Letsch A,

Loddenkemper C, Stroux A, Bauer S, Thiel E, Keilholz U. Identification of

truncated chemokine receptor 7 in human colorectal cancer unable to localize to

the cell surface and unreactive to external ligands. Int J Cancer. 2008 Oct

1;123(7):1565-72. doi: 10.1002/ijc.23704. PubMed PMID: 18623114.

 

Nadobny J, Szimtenings M, Diehl D, Stetter E, Brinker G, Wust P. Evaluation

of MR-induced hot spots for different temporal SAR modes using a time-dependent

finite difference method with explicit temperature gradient treatment. IEEE Trans

Biomed Eng. 2007 Oct;54(10):1837-50. PubMed PMID: 17926682.

 

Wust P. [They should make thermotherapy more effective. Hot nanoparticles

against cancer]. MMW Fortschr Med. 2007 Aug 16;149(33-34):16. German. PubMed

PMID: 17915367.

 

Gellermann J, Göke J, Figiel R, Weihrauch M, Cho CH, Budach V, Felix R, Wust

P. Simulation of different applicator positions for treatment of a presacral

tumour. Int J Hyperthermia. 2007 Feb;23(1):37-47. PubMed PMID: 17575722.

 

Wust P, Nadobny J, Szimtenings M, Stetter E, Gellermann J. Implications of

clinical RF hyperthermia on protection limits in the RF range. Health Phys. 2007

Jun;92(6):565-73. Review. PubMed PMID: 17495657.

 

Wust P, Gneveckow U, Johannsen M, Böhmer D, Henkel T, Kahmann F, Sehouli J,

Felix R, Ricke J, Jordan A. Magnetic nanoparticles for interstitial

thermotherapy--feasibility, tolerance and achieved temperatures. Int J

Hyperthermia. 2006 Dec;22(8):673-85. PubMed PMID: 17390997.

 

Hildebrandt B, Schoeler D, Ringel F, Kerner T, Wust P, Riess H, Schriever F.

Differential gene expression in peripheral blood lymphocytes of cancer patients

treated with whole body hyperthermia and chemotherapy: a pilot study. Int J

Hyperthermia. 2006 Dec;22(8):625-35. PubMed PMID: 17390994.

 

Johannsen M, Gneveckow U, Thiesen B, Taymoorian K, Cho CH, Waldöfner N,

Scholz R, Jordan A, Loening SA, Wust P. Thermotherapy of prostate cancer using

magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature

distribution. Eur Urol. 2007 Dec;52(6):1653-61. Epub 2006 Nov 17. PubMed PMID:

17125906.

 

Gellermann J, Hildebrandt B, Issels R, Ganter H, Wlodarczyk W, Budach V,

Felix R, Tunn PU, Reichardt P, Wust P. Noninvasive magnetic resonance

thermography of soft tissue sarcomas during regional hyperthermia: correlation

with response and direct thermometry. Cancer. 2006 Sep 15;107(6):1373-82. PubMed

PMID: 16902986.

 

Maier-Hauff K, Rothe R, Scholz R, Gneveckow U, Wust P, Thiesen B, Feussner

A, von Deimling A, Waldoefner N, Felix R, Jordan A. Intracranial thermotherapy

using magnetic nanoparticles combined with external beam radiotherapy: results of

a feasibility study on patients with glioblastoma multiforme. J Neurooncol. 2007

Jan;81(1):53-60. Epub 2006 Jun 14. PubMed PMID: 16773216.

 

Plotkin M, Gneveckow U, Meier-Hauff K, Amthauer H, Feussner A, Denecke T,

Gutberlet M, Jordan A, Felix R, Wust P. 18F-FET PET for planning of thermotherapy

using magnetic nanoparticles in recurrent glioblastoma. Int J Hyperthermia. 2006

Jun;22(4):319-25. PubMed PMID: 16754352.

 

Wust P, Cho CH, Hildebrandt B, Gellermann J. Thermal monitoring: invasive,

minimal-invasive and non-invasive approaches. Int J Hyperthermia. 2006

May;22(3):255-62. Review. PubMed PMID: 16754347.

 

Ghadjar P, Coupland SE, Na IK, Noutsias M, Letsch A, Stroux A, Bauer S, Buhr

HJ, Thiel E, Scheibenbogen C, Keilholz U. Chemokine receptor CCR6 expression

level and liver metastases in colorectal cancer. J Clin Oncol. 2006 Apr

20;24(12):1910-6. PubMed PMID: 16622267.

 

van Rhoon GC, Wust P. Introduction: non-invasive thermometry for

thermotherapy. Int J Hyperthermia. 2005 Sep;21(6):489-95. PubMed PMID: 16147435.

 

Gellermann J, Wlodarczyk W, Hildebrandt B, Ganter H, Nicolau A, Rau B, Tilly

W, Fähling H, Nadobny J, Felix R, Wust P. Noninvasive magnetic resonance

thermography of recurrent rectal carcinoma in a 1.5 Tesla hybrid system. Cancer

Res. 2005 Jul 1;65(13):5872-80. PubMed PMID: 15994965.

 

Nadobny J, Wlodarczyk W, Westhoff L, Gellermann J, Felix R, Wust P. A

clinical water-coated antenna applicator for MR-controlled deep-body

hyperthermia: a comparison of calculated and measured 3-D temperature data sets.

IEEE Trans Biomed Eng. 2005 Mar;52(3):505-19. PubMed PMID: 15759581.

 

Gellermann J, Wlodarczyk W, Ganter H, Nadobny J, Fähling H, Seebass M, Felix

R, Wust P. A practical approach to thermography in a hyperthermia/magnetic

resonance hybrid system: validation in a heterogeneous phantom. Int J Radiat

Oncol Biol Phys. 2005 Jan 1;61(1):267-77. PubMed PMID: 15629620.