Publications

Authors:Ingeborg Tinhofer, Stephanie Staudte, Stephen George

Title:Liquid biopsy in head neck cancer: ready for clinical routine diagnostics?

Journal:Curr Opin Oncol . Year:2023;

Authors:Alberto D'Angelo, Huseyin Kilili , Robert Chapman , Daniele Generali , Ingeborg Tinhofer , Stefano Luminari , Benedetta Donati , Alessia Ciarrocchi , Riccardo Giannini , Roberto Moretto , Chiara Cremolini , Filippo Pietrantonio , Navid Sobhani , Debora Bonazza , Robert Prins , Seung Geun Song , Yoon Kyung Jeon , Giuseppina Pisignano , Mattia Cinelli , Stefan Bagby , Araxi O Urrutia

Title:Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses

Journal:PLoS One Year:2023;

Authors:Asier Rabasco Meneghetti, Alex Zwanenburg, Annett Linge, Fabian Lohaus, Marianne Grosser, Gustavo B Baretton, Goda Kalinauskaite, Ingeborg Tinhofer, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Jens von der Grün, Ute Ganswindt, Claus Belka, Jan C Peeken, Stephanie E Combs, Simon Böke, Daniel Zips, Esther G C Troost, Mechthild Krause, Michael Baumann, Steffen Löck

Title:Integrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC

Journal:Sci Rep. Year:2022;

Authors:Julia Hess, Kristian Unger, Cornelius Maihoefer, Lars Schüttrumpf, Peter Weber, Sebastian Marschner, Ludmila Wintergerst, Ulrike Pflugradt, Philipp Baumeister, Axel Walch, Christine Woischke, Thomas Kirchner, Martin Werner, Kristin Sörensen, Michael Baumann, Ingeborg Tinhofer, Stephanie E Combs, Jürgen Debus, Henning Schäfer, Mechthild Krause, Annett Linge, Jens von der Grün, Martin Stuschke, Daniel Zips, Martin Canis, Kirsten Lauber, Ute Ganswindt, Michael Henke, Horst Zitzelsberger, Claus Belka

Title:Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients

Journal:Cancers (Basel) Year:2022;

Authors:Shivaprasad Patil, Annett Linge, Hannah Hiepe, Marianne Grosser, Fabian Lohaus, Volker Gudziol, Max Kemper, Alexander Nowak, Dominik Haim, Inge Tinhofer, Volker Budach, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Jens von der Grün, Henning Schäfer, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Simon Boeke, Daniel Zips, Korinna Jöhrens, Gustavo B Baretton, Michael Baumann, Mechthild Krause, Steffen Löck, On Behalf Of The Dktk-Rog

Title:A Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT

Journal:Cancers (Basel) Year:2022;

Authors:Stephanie Staudte, Konrad Klinghammer, Philipp Sebastian Jurmeister, Paul Jank, Jens-Uwe Blohmer, Sandra Liebs, Peter Rhein, Anja E Hauser, Ingeborg Tinhofer

Title:Multiparametric Phenotyping of Circulating Tumor Cells for Analysis of Therapeutic Targets, Oncogenic Signaling Pathways and DNA Repair Markers

Journal:Cancers (Basel) Year:2022;

Authors:Shivaprasad Patil, Annett Linge, Marianne Grosser, Fabian Lohaus, Volker Gudziol, Max Kemper, Alexander Nowak, Dominik Haim, Inge Tinhofer, Volker Budach, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Henning Schäfer, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Simon Boeke, Daniel Zips, Gustavo B Baretton, Michael Baumann, Mechthild Krause, Steffen Löck; DKTK-ROG 2

Title:Development and validation of a 6-gene signature for the prognosis of loco-regional control in patients with HPV-negative locally advanced HNSCC treated by postoperative radio(chemo)therapy

Journal:Radiother Oncol. Year:2022;

Authors:Steffen Löck, Annett Ling, Fabian Lohaus, Nadja Ebert, Volker Gudziol, Alexander Nowak, Ingeborg Tinhofer, Goda Kalinauskaite, Maja Guberina, Martin Stuschke, Panagiotis Balermpa, Jens von der Grün, Anca-Ligia Grosu, Jürgen Debus, Ute Ganswindt, Claus Belka, Jan C Peeken, Stephanie E Combs, Chiara De-Colle, Daniel Zips, Gustavo B Baretton, Mechthild Krause, Michael Baumann; DKTK-ROG

Title:Biomarker signatures for primary radiochemotherapy of locally advanced HNSCC - Hypothesis generation on a multicentre cohort of the DKTK-ROG

Journal:Radiother Oncol. Year:2022;

Authors:Bouchra Tawk, Ute Wirkner, Christian Schwager, Katrin Rein, Karim Zaoui, Philippe A Federspil, Sebastian Adeberg, Annett Linge, Ute Ganswindt, Julia Hess, Kristian Unger, Ingeborg Tinhofer, Volker Budach, Fabian Lohaus, Mechthild Krause, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca L Grosu, Henning Schäfer, Daniel Zips, Stephanie E Combs, Steffi Pigorsch, Horst Zitzelsberger, Philipp Baumeister, Thomas Kirchner, Melanie Bewerunge-Hudler, Wilko Weichert, Jochen Hess, Esther Herpel, Claus Belka, Michael Baumann, Jürgen Debus, Amir Abdollahi; DKTK-ROG

Title:Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy

Journal:Int J Cancer. Year:2022;

Authors:Shivaprasad Patil, Bouchra Tawk, Marianne Grosser, Fabian Lohaus, Volker Gudziol, Max Kemper, Alexander Nowak, Dominik Haim, Inge Tinhofer, Volker Budach, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Henning Schäfer, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Simon Boeke Daniel Zips, Gustavo B Baretton, Michael Baumann, Mechthild Krause, Steffen Löck, Annett Linge; DKTK-ROG

Title:Analyses of molecular subtypes and their association to mechanisms of radioresistance in patients with HPV-negative HNSCC treated by postoperative radiochemotherapy

Journal:Radiother Oncol. Year:2022;

Authors:D Martin, T Schreckenbach, P Ziegler, N Filmann, G Kalinauskaite, I Tinhofer, V Budach, C Gani, D Zips, T Schimek-Jasch, H Schäfer, A L Grosu, E Thomas, M Krause, H Dapper, S Combs, C Hoffmann, M Stuschke, F Walter, C Belka, I Kurth, W W Hadiwikarta, M Baumann, C Rödel, E Fokas

Title:Evaluation of prognostic factors after primary chemoradiotherapy of anal cancer: A multicenter study of the German Cancer Consortium-Radiation Oncology Group (DKTK-ROG)

Journal:Radiother Oncol. Year:2022;

Authors:Raphaela Graessle, Carmen Stromberger, Max Heiland, Christian Doll, Veit M Hofmann, Konrad Klinghammer, Ingeborg Tinhofer, Heidi Olze, Marcus Beck, Philipp Arens, Steffen Dommerich, Iris Piwonski, Annekatrin Coordes

Title:Predictors for Adherence to Treatment Strategies in Elderly HNSCC Patients

Journal:Cancers (Basel) Year:2022;

Authors:Tawk B, Wirkner U, Schwager C, Rein K, Zaoui K, Federspil PA, Adeberg S, Linge A, Ganswindt U, Hess J, Unger K, Tinhofer I, Budach V, Lohaus F, Krause M, Guberina M, Stuschke M, Balermpas P, Rödel C, Grosu AL, Schäfer H, Zips D, Combs SE, Pigorsch S, Zitzelsberger H, Baumeister P, Kirchner T, Bewerunge-Hudler M, Weichert W, Hess J, Herpel E, Belka C, Baumann M, Debus J, Abdollahi A, DKTK-ROG

Title:Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy

Journal:Int J Cancer. Year:2021;

Authors:Galot R, Le Tourneau C, Saada-Bouzid E, Daste A, Even C, Debruyne P, Henry S, Zanetta S, Rutten A, Licitra L, Canon JL, Kaminsky MC, Specenier P, Rottey S, Guigay J, Kong A, Tinhofer I, Borcoman E, Dirix L, Raveloarivahy T, Fortpied C, Vanlancker M, Morfouace M, Govaerts AS, Machiels JP.

Title:A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial

Journal:Eur J Cancer. Year:2021;

Authors:Amler AK, Schlauch D, Tüzüner S, Thomas A, Neckel N, Tinhofer I, Heiland M, Lauster R, Kloke L, Stromberger C, Nahles S.

Title:Pilot investigation on the dose-dependent impact of irradiation on primary human alveolar osteoblasts in vitro

Journal:Sci Rep. Year:2021;

Authors:Sandra Liebs, Theresa Eder, Frederick Klauschen, Moritz Schütte, Marie-Laure Yaspo, Ulrich Keilholz, Ingeborg Tinhofer, Evelyn Kidess-Sigal, Diana Braunholz

Title:Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities

Journal:Oncogene. Year:2021;

Authors:Minli Niu, Stephanie E Combs, Annett Linge, Mechthild Krause, Michael Baumann , Fabian Lohaus, Nadja Ebert, Ingeborg Tinhofer, Volker Budach, Jens von der Grün, Franz Rödel, Anca-Ligia Grosu, Gabriele Multhoff

Title:Comparison of the composition of lymphocyte subpopulations in non-relapse and relapse patients with squamous cell carcinoma of the head and neck before, during radiochemotherapy and in the follow-up period: a multicenter prospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)

Journal:Radiat Oncol. Year:2021;

Authors:Claudius Jelgersma, Carolin Senger, Anne Kathrin Kluge, Anastasia Janas, Melina Nieminen-Kelhä, Irina Kremenetskaia, Susanne Mueller, Susan Brandenburg, Franziska Loebel, Ingeborg Tinhofer, Alfredo Conti, Volker Budach, Peter Vajkoczy, Gueliz Acker

Title:Establishment and Validation of CyberKnife Irradiation in a Syngeneic Glioblastoma Mouse Model

Journal:Cancers (Basel) Year:2021;

Authors:Sebastian Zschaeck, Julian Weingärtner, Pirus Ghadjar, Peter Wust, Felix Mehrhof, Goda Kalinauskaite, Vincent H Ehrhardt, Vivian Hartmann, Ingeborg Tinhofer, Max Heiland, Annekatrin Coordes, Grzegorz Kofla, Volker Budach, Carmen Stromberger, Marcus Beck

Title:Fever range whole body hyperthermia for re-irradiation of head and neck squamous cell carcinomas: Final results of a prospective study

Journal:Oral Oncol. Year:2021;

Authors:Carmen Stromberger, Berna Yedikat, Annekatrin Coordes, Ingeborg Tinhofer, Goda Kalinauskaite, Volker Budach, Sebastian Zschaeck, Jan-Dirk Raguse, Grzegorz Kofla, Max Heiland, Aksana Stsefanenka, Benedicta Beck-Broichsitter, Steffen Dommerich, Carolin Senger, Marcus Beck

Title:Prognostic Factors Predict Oncological Outcome in Older Patients With Head and Neck Cancer Undergoing Chemoradiation Treatment

Journal:Front Oncol. Year:2021;

Authors:Gronbach L, Jurmeister P, Schäfer-Korting M, Keilholz U, Tinhofer I, Zoschke C.

Title:Primary Extracellular Matrix Enables Long-Term Cultivation of Human Tumor Oral Mucosa Models

Journal:Front Bioeng Biotechnol. Year:2020;

Authors:Leger S, Zwanenburg A, Leger K, Lohaus F, Linge A, Schreiber A, Kalinauskaite G, Tinhofer I, Guberina N, Guberina M, Balermpas P, von der Grün J, Ganswindt U, Belka C, Peeken JC, Combs SE, Boeke S, Zips D, Richter C, Krause M, Baumann M, Troost EGC, Löck S.

Title:Comprehensive Analysis of Tumour Sub-Volumes for Radiomic Risk Modelling in Locally Advanced HNSCC

Journal:Cancers (Basel) Year:2020; Volume:12Issue:(10):Pages:3047.

Authors:Messerschmidt C, Obermayer B, Klinghammer K, Ochsenreither S, Treue D, Stenzinger A, Glimm H, Fröhling S, Kindler T, Brandts CH, Schulze-Osthoff K, Weichert W, Tinhofer I, Klauschen F, Keilholz U, Beule D, Rieke DT.

Title:Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

Journal:Int J Cancer Year:2020; Volume:147Issue:(8):Pages:2293-2302.

Authors:Tinhofer I, Braunholz D, Klinghammer K.

Title:Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies

Journal:Cancers Head Neck Year:2020;

Authors:Kalinauskaite G, Senger C, Kluge A, Furth C, Kufeld M, Tinhofer I, Budach V, Beck M, Hochreiter A, Grün A, Stromberger C.

Title:68Ga-PSMA-PET/CT-based radiosurgery and stereotactic body radiotherapy for oligometastatic prostate cancer.

Journal:PLoS One Year:2020; Volume:15Issue:(10):Pages:e0240892.

Authors:G. Kalinauskaite, I. Tinhofer, M. Kufeld, A. Kluge, A. Grün, V. Budach, C. Senger & C. Stromberger

Title:Radiosurgery and fractionated stereotactic body radiotherapy for patients with lung oligometastases

Journal:BMC Cancer Year:2020; Volume:20Issue:(1):Pages:404.

Authors:Reuschenbach, M.; Tinhofer, I.; Wittekindt, C.; Wagner, S.; Klussmann, J. P.

Title:A systematic review of the HPV-attributable fraction of oropharyngeal squamous cell carcinomas in Germany

Journal:Cancer Med Year:2019; Volume:8Issue:(4):Pages:1908-1918.

Authors:Budach, V.; Tinhofer, I.

Title:Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review

Journal:Lancet Oncol Year:2019; Volume:20Issue:(6):Pages:e313-e326.

Authors:Eder, T.; Hess, A. K.; Konschak, R.; Stromberger, C.; Johrens, K.; Fleischer, V.;
Hummel, M.; Balermpas, P.; von der Grun, J.; Linge, A.; Lohaus, F.; Krause, M.; Baumann, M.; Stuschke, M.; Zips, D.; Grosu, A. L.; Abdollahi, A.; Debus, J.; Belka, C.;
Pigorsch, S.; Combs, S. E.; Budach, V.; Tinhofer, I.; Dktk, R. O. G.

Title:Interference of tumour mutational burden with outcome of patients with head and neck cancer treated with definitive chemoradiation: a multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group

Journal:Eur J Cancer Year:2019; Volume:116:Pages:67-76.

Authors:Hess, A. K.; Johrens, K.; Zakarneh, A.; Balermpas, P.; Von Der Grun, J.; Rodel, C.; Weichert, W.; Hummel, M.; Keilholz, U.; Budach, V.; Tinhofer, I.

Title:Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas

Journal:Oncoimmunology Year:2019; Volume:8Issue:(8):Pages:1614858.

Authors:Galot R, Le Tourneau C, Guigay J, Licitra L, Tinhofer I, Kong A, Caballero C, Fortpied C, Bogaerts J, Govaerts AS, Staelens D, Raveloarivahy T, Rodegher L, Laes JF, Saada-Bouzid E, Machiels JP.

Title:"Personalized biomarker-based treatment strategy for patients with squamous cell carcinoma of the head and neck: EORTC position and approach."

Journal:Ann Oncol Year:2018;

Authors:Tinhofer I, Staudte S

Title:Circulating tumor cells as biomarkers in head and neck cancer: recent advances and future outlook.

Journal:Expert Rev Mol Diagn Year:2018; Volume:18:Pages:897-906.

Authors:Schmidt S, Linge A, Zwanenburg A, Leger S, Lohaus F, Krenn C, Appold S, Gudziol V, Nowak A, von Neubeck C, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch SU, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Baumann M, Krause M, Löck S.

Title:Development and validation of a gene signature for patients with head and neck squamous cell carcinomas treated by postoperative radio(chemo)therapy.

Journal:Clin Cancer Res Year:2018; Volume:24Issue:(6):Pages:1364-1374.

Authors:Leger S, Zwanenburg A, Pilz K, Lohaus F, Linge A, Zöphel K, Kotzerke J, Schreiber A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Krause M, Baumann M, Troost EGC, Löck S, Richter C

Title:A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling.

Journal:Sci Rep Year:2017; Volume:7Issue:(1):Pages:13206.

Authors:Klinghammer K, Otto R, Raguse JD, Albers AE, Tinhofer I, Fichtner I, Leser U, Keilholz U, Hoffmann J

Title:Basal subtype is predictive for response to cetuximab treatment in patient-derived xenografts of squamous cell head and neck cancer.

Journal:Int J Cancer Year:2017; Volume:141Issue:(6):Pages:1215-1221.

Authors:Balermpas P, Rödel F, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Sak A, Stuschke M, Gkika E, Grosu AL, Abdollahi A, Debus J, Stangl S, Ganswindt U, Belka C, Pigorsch S, Multhoff G, Combs SE, Welz S, Zips D, Lim SY, Rödel C, Fokas E; DKTK-ROG

Title:The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Journal:Int J Cancer Year:2017; Volume:141Issue:(3):Pages:594-603.

Authors:Hess AK, Müer A, Mairinger FD, Weichert W, Stenzinger A, Hummel M, Budach V, Tinhofer

Title:MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.

Journal:Eur J Cancer Year:2017; Volume:77:Pages:3-12.

Authors:Balermpas P, Rödel F, Rödel C, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Gkika E, Stuschke M, Avlar M, Grosu AL, Abdollahi A, Debus J, Bayer C, Stangl S, Belka C, Pigorsch S, Multhoff G, Combs SE, Mönnich D, Zips D, Fokas E.

Title:CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG)

Journal:Int J Cancer Year:2016; Volume:138Issue:(1):Pages:171-181.

Authors:Raguse JD, Hossamo J, Tinhofer I, Hoffmeister B, Budach V, Jamil B, Jöhrens K, Thieme N, Doll C, Nahles S, Hartwig ST, Stromberger C.

Title:Patient and treatment-related risk factors for osteoradionecrosis of the jaw in patients with head and neck cancer

Journal:Oral Surg Oral Med Oral Pathol Oral Radiol Year:2016; Volume:121Issue:(3):Pages:215-221.

Authors:Tinhofer I, Budach V, Saki M, Konschak R, Niehr F, Jöhrens K, Weichert W, Linge A, Lohaus F, Krause M, Neumann K, Endris V, Sak A, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu AL, Abdollahi A, Debus J, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Baumann M; DKTK-ROG.

Title:Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation

Journal:Eur J Cancer Year:2016; Volume:57:Pages:78-86.

Authors:Heß AK, Weichert W, Budach V, Tinhofer I.

Title:[The role of microRNAs in head and neck squamous cell carcinoma : Biomarkers for prognosis, therapy selection, and novel therapeutics]

Journal:HNO Year:2016; Volume:64Issue:(5):Pages:296-302.

Authors:Linge A, Löck S, Gudziol V, Nowak A, Lohaus F, von Neubeck C, Jütz M, Abdollahi A, Debus J, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu AL, Bayer C, Belka C, Pigorsch S, Combs SE, Welz S, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Baumann M, Krause M; DKTK-ROG.

Title:Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG

Journal:Clin Cancer Res Year:2016; Volume:22Issue:(11):Pages:2639-49.

Authors:Braunholz D, Saki M, Niehr F, Öztürk M, Borràs Puértolas B, Konschak R, Budach V, Tinhofer I.

Title:Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival

Journal:PLoS One Year:2016; Volume:11Issue:(9):Pages:e0163149.

Authors:Meucci S, Keilholz U, Tinhofer I, Ebner OA.

Title:Mutational load and mutational patterns in relation to age in head and neck cancer

Journal:Oncotarget Year:2016; Volume:7Issue:(43):Pages:69188-69199.

Authors:Rieke DT, Ochsenreither S, Klinghammer K, Seiwert TY, Klauschen F, Tinhofer I, Keilholz U.

Title:Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Journal:Oncotarget Year:2016; Volume:7Issue:(46):Pages:75379-75393.

Authors:Linge A, Lohaus F, Löck S, Nowak A, Gudziol V, Valentini C, von Neubeck C, Jütz M, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Krause M, Baumann M; DKTK-ROG.

Title:HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre study of the DKTK-ROG

Journal:Radiother Oncol Year:2016; Volume:121Issue:(3):Pages:364-373.

Authors:Kidess-Sigal E, Liu HE, Triboulet MM, Che J, Ramani VC, Visser BC, Poultsides GA, Longacre TA, Marziali A, Vysotskaia V, Wiggin M, Heirich K, Hanft V, Keilholz U, Tinhofer I, Norton JA, Lee M, Sollier-Christen E, Jeffrey SS.

Title:Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer

Journal:Oncotarget Year:2016; Volume:7Issue:(51):Pages:85349-85364.

Authors:Tinhofer I, Niehr F, Konschak R, Liebs S, Munz M, Stenzinger A, Weichert W, Keilholz U, Budach V

Title:Next-generation sequencing: hype and hope for development of personalized radiation therapy?

Journal:Radiat Oncol Year:2015; Volume:10:Pages:183.

Authors:Wagner S, Würdemann N, Hübbers C, Reuschenbach M, Prigge ES, Wichmann G, Hess J, Dietz A, Dürst M, Tinhofer I, von Knebel-Döberitz M, Wittekindt C, Klussmann JP.

Title:[HPV-associated head and neck cancer : mutational signature and genomic aberrations].

Journal:HNO Year:2015; Volume:63Issue:(11):Pages:758-67.

Authors:Niehr F, Weichert W, Stenzinger A, Budach V, Tinhofer I

Title:CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin

Journal:J Transl Med Year:2015; Volume:13

Authors:Tinhofer I, Jöhrens K, Keilholz U, Kaufmann A, Lehmann A, Weichert W, Stenzinger A, Stromberger C, Klinghammer K, Becker ET, Dommerich S, Stölzel K, Hofmann VM, Hildebrandt B, Moser L, Ervens J, Böttcher A, Albers A, Stabenow R, Reinecke A, Budach V, Hoffmeister B, Raguse JD

Title:Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence

Journal:Eur J Cancer Year:2015; Volume:51Issue:(4):Pages:514-521.

Authors:Stromberger C, Jann D, Becker ET, Raguse JD, Tinhofer I, Marnitz S, Budach V

Title:Adjuvant simultaneous integrated boost IMRT for patients with intermediate- and high-risk head and neck cancer: outcome, toxicities and patterns of failure

Journal:Oral Oncol Year:2014; Volume:50Issue:(11):Pages:1114–1121.

Authors:Tinhofer I, Saki M, Niehr F, Keilholz U, Budach V

Title:Cancer stem cell characteristics of circulating tumor cells

Journal:Int J Radiat Biol Year:2014; Volume:90Issue:(8):Pages:622-627.

Authors:Boyko-Fabian M, Niehr F, Distel L, Budach V, Tinhofer I

Title:Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma cells with functional p53 deficiency and resistance to EGFR blockade

Journal:PloS one Year:2014; Volume:9Issue:(6)

Authors:Tinhofer I, Konschak R, Stromberger C, Raguse JD, Dreyer JH, Jöhrens K, Keilholz U, Budach V

Title:Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck

Journal:Ann Oncol Year:2014; Volume:25Issue:(10):Pages:2042-2047.

Authors:Lohaus F, Linge A, Tinhofer I, Budach V, Gkika E, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu AL, Abdollahi A, Debus J, Bayer C, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, von Neubeck C, Baretton GB, Löck S, Thames HD, Krause M, Baumann M; DKTK-ROG

Title:HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group

Journal:Radiother Oncol. Year:2014; Volume:113Issue:(3):Pages:317–323.

Authors:Chen C, Zimmermann M, Tinhofer I, Kaufmann AM, Albers AE.

Title:Epithelial-to-mesenchymal transition and cancer stem(-like) cells in head and neck squamous cell carcinoma

Journal:Cancer Lett. Year:2012; Volume:Jul 4

Authors:Gorges TM, Tinhofer I, Drosch M, Roese L, Zollner TM, Krahn T, von Ahsen O.

Title:Circulating tumor cells escape from EpCAM-based detection due to epithelial-to mesenchymal transition.

Journal:BMC Cancer Year:2012; Volume:12Issue:(1):Pages:178.

Authors:Hristozova T, Konschak R, Budach V, Tinhofer I.

Title:A simple multicolor flow cytometry protocol for detection and response to irradiation and cetuximab in head and neck cancer molecular characterization of circulating tumor cells in epithelial cancers

Journal:Cytometry A Year:2012; Volume:81Issue:(6):Pages:489-95.

Authors:Tinhofer I, Hristozova T, Stromberger C, Keilholz U, Budach V.

Title:Monitoring of circulating tumor cells and their expression of EGFR/phospho-EGFR during combined radiotherapy regimens in locally advanced squamous cell carcinoma of the head and neck

Journal:Int J Radiat Oncol Biol Phys Year:2012; Volume:83Issue:(5):Pages:e685-90.

Authors:Holz C, Niehr F, Boyko M, Hristozova T, Distel L, Budach V, Tinhofer I.

Title:Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells

Journal:Radiother Oncol Year:2011; Volume:101Issue:(1):Pages:158-64.

Authors:Tinhofer I, Klinghammer K, Weichert W, Knödler M, Stenzinger A, Gauler T,
Budach V, Keilholz U.

Title:Expression of Amphiregulin and EGFRvIII Affect Outcome of Patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) Receiving Cetuximab-Docetaxel Treatment

Journal:Clin Cancer Res Year:2011; Volume:17Issue:(15):Pages:5197-204.

Authors:Hristozova T, Konschak R, Stromberger C, Fusi A, Liu Z, Weichert W, Stenzinger
A, Budach V, Keilholz U, Tinhofer I.

Title:The presence of circulating tumor cells correlates with lymph node metastasis in nonresectable squamous cell carcinoma of the head and neck region (SCCHN)

Journal:Anal Oncol Year:2011; Volume:22Issue:(8):Pages:1878-85.

Authors:Liu Z, Fusi A, Klopocki E, Schmittel A, Tinhofer I, Nonnenmacher A, Keilholz
U.

Title:Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

Journal:J Transl Med Year:2011; Volume:May 19Issue:(9):Pages:70.

Authors:Konschak R, Tinhofer I.

Title:Prestaining of PCR products with SYBR Green for agarose gel electrophoresis: advantages and limitations

Journal:Clin Chem Lab Med Year:2011; Volume:49Issue:(6):Pages:1069-71.

Authors:Budach V, Stuschke M, Budach W, Baumann M, Geismar D, Grabenbauer G, Lammert I, Jahnke K, Stueben G, Herrmann T, Bamberg M, Wust P, Hinkelbein W, Wernecke KD

Title:Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer

Journal:J Clin Oncol Year:2005; Volume:23Issue:(6):Pages:1125-35.

Authors:Sak A, Wurm R, Elo B, Grehl S, Pöttgen C, Stüben G, Sinn B, Wolf G, Budach V,
Stuschke M

Title:Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21(WAF1/CIP1)

Journal:Cancer Gene Ther Year:2003; Volume:10Issue:(12):Pages:926-34.

Authors:Sak A, Stuschke M, Wurm R, Schroeder G, Sinn B, Wolf G, Budach V.

Title:Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines

Journal:Cancer Res Year:2002; Volume:62Issue:(22):Pages:6621-24.

Authors:Stuschke M, Sak A, Wurm R, Sinn B, Wolf G, Stüben G, Budach V.

Title:Radiation-induced apoptosis in human non-small-cell lung cancer cell lines is secondary to cell-cycle progression beyond the G2-phase checkpoint

Journal:Int J Radiat Biol Year:2002; Volume:78Issue:(9):Pages:807-19.

Authors:Budach W, Budach V

Title:Association of tumor growth on nude mice and poor clinical outcome in soft tissue sarcoma patients

Journal:J Cancer Res Clin Oncol Year:2001; Volume:127Issue:(9):Pages:523-30.